The effects of subthalamic deep brain stimulation on metaphor comprehension and language abilities in Parkinson's disease.
Identifieur interne : 000503 ( Main/Exploration ); précédent : 000502; suivant : 000504The effects of subthalamic deep brain stimulation on metaphor comprehension and language abilities in Parkinson's disease.
Auteurs : Christina Tremblay [Canada] ; Joël Macoir [Canada] ; Mélanie Langlois [Canada] ; Léo Cantin [Canada] ; Michel Prud'Homme [Canada] ; Laura Monetta [Canada]Source :
- Brain and language [ 1090-2155 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- physiopathology : Parkinson Disease, Subthalamic Nucleus.
- psychology : Parkinson Disease.
- therapy : Parkinson Disease.
- Aged, Comprehension, Deep Brain Stimulation, Female, Humans, Language, Male, Metaphor, Middle Aged.
Abstract
The effects of subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) on different language abilities are still controversial and its impact on high-level language abilities such as metaphor comprehension has been overlooked. The aim of this study was to determine the effects of STN electrical stimulation on metaphor comprehension and language abilities such as lexical and semantic capacities. Eight PD individuals with bilateral STN-DBS were first evaluated OFF-DBS and, at least seven weeks later, ON-DBS. Performance on metaphor comprehension, lexical decision, word association and verbal fluency tasks were compared ON and OFF-DBS in addition to motor symptoms evaluation. STN stimulation had a significant beneficial effect on motor symptoms in PD. However, this stimulation did not have any effect on metaphor comprehension or any other cognitive ability evaluated in this study. These outcomes suggest that STN stimulation may have dissociable effects on motor and language functions.
DOI: 10.1016/j.bandl.2014.12.004
PubMed: 25577507
Affiliations:
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Electronic address: christina.tremblay.1@ulaval.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculté de médecine, Département de réadaptation, Université Laval, 1050, ave de la Médecine, Québec, QC G1V 0A6, Canada; Institut Universitaire en Santé Mentale de Québec, 2601, rue de la Canardière, Québec, QC G1J 2G3</wicri:regionArea><wicri:noRegion>QC G1J 2G3</wicri:noRegion></affiliation></author><author><name sortKey="Macoir, Joel" sort="Macoir, Joel" uniqKey="Macoir J" first="Joël" last="Macoir">Joël Macoir</name><affiliation wicri:level="1"><nlm:affiliation>Faculté de médecine, Département de réadaptation, Université Laval, 1050, ave de la Médecine, Québec, QC G1V 0A6, Canada; Institut Universitaire en Santé Mentale de Québec, 2601, rue de la Canardière, Québec, QC G1J 2G3, Canada. 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Electronic address: Melanie.Langlois.cha@ssss.gouv.qc.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Clinique des troubles du mouvement, Hôpital de l'Enfant-Jésus, 1401, 18(e) rue, Québec, QC G1J 1Z4</wicri:regionArea><wicri:noRegion>QC G1J 1Z4</wicri:noRegion></affiliation></author><author><name sortKey="Cantin, Leo" sort="Cantin, Leo" uniqKey="Cantin L" first="Léo" last="Cantin">Léo Cantin</name><affiliation wicri:level="1"><nlm:affiliation>Clinique des troubles du mouvement, Hôpital de l'Enfant-Jésus, 1401, 18(e) rue, Québec, QC G1J 1Z4, Canada. 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Electronic address: michel.prudhomme.chuq@gmail.com.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Clinique des troubles du mouvement, Hôpital de l'Enfant-Jésus, 1401, 18(e) rue, Québec, QC G1J 1Z4</wicri:regionArea><wicri:noRegion>QC G1J 1Z4</wicri:noRegion></affiliation></author><author><name sortKey="Monetta, Laura" sort="Monetta, Laura" uniqKey="Monetta L" first="Laura" last="Monetta">Laura Monetta</name><affiliation wicri:level="1"><nlm:affiliation>Faculté de médecine, Département de réadaptation, Université Laval, 1050, ave de la Médecine, Québec, QC G1V 0A6, Canada; Institut Universitaire en Santé Mentale de Québec, 2601, rue de la Canardière, Québec, QC G1J 2G3, Canada. Electronic address: laura.monetta@rea.ulaval.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculté de médecine, Département de réadaptation, Université Laval, 1050, ave de la Médecine, Québec, QC G1V 0A6, Canada; Institut Universitaire en Santé Mentale de Québec, 2601, rue de la Canardière, Québec, QC G1J 2G3</wicri:regionArea><wicri:noRegion>QC G1J 2G3</wicri:noRegion></affiliation></author></analytic><series><title level="j">Brain and language</title><idno type="eISSN">1090-2155</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Comprehension</term><term>Deep Brain Stimulation</term><term>Female</term><term>Humans</term><term>Language</term><term>Male</term><term>Metaphor</term><term>Middle Aged</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (therapy)</term><term>Subthalamic Nucleus (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Comprehension</term><term>Deep Brain Stimulation</term><term>Female</term><term>Humans</term><term>Language</term><term>Male</term><term>Metaphor</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effects of subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) on different language abilities are still controversial and its impact on high-level language abilities such as metaphor comprehension has been overlooked. The aim of this study was to determine the effects of STN electrical stimulation on metaphor comprehension and language abilities such as lexical and semantic capacities. Eight PD individuals with bilateral STN-DBS were first evaluated OFF-DBS and, at least seven weeks later, ON-DBS. Performance on metaphor comprehension, lexical decision, word association and verbal fluency tasks were compared ON and OFF-DBS in addition to motor symptoms evaluation. STN stimulation had a significant beneficial effect on motor symptoms in PD. However, this stimulation did not have any effect on metaphor comprehension or any other cognitive ability evaluated in this study. These outcomes suggest that STN stimulation may have dissociable effects on motor and language functions.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Tremblay, Christina" sort="Tremblay, Christina" uniqKey="Tremblay C" first="Christina" last="Tremblay">Christina Tremblay</name></noRegion><name sortKey="Cantin, Leo" sort="Cantin, Leo" uniqKey="Cantin L" first="Léo" last="Cantin">Léo Cantin</name><name sortKey="Langlois, Melanie" sort="Langlois, Melanie" uniqKey="Langlois M" first="Mélanie" last="Langlois">Mélanie Langlois</name><name sortKey="Macoir, Joel" sort="Macoir, Joel" uniqKey="Macoir J" first="Joël" last="Macoir">Joël Macoir</name><name sortKey="Monetta, Laura" sort="Monetta, Laura" uniqKey="Monetta L" first="Laura" last="Monetta">Laura Monetta</name><name sortKey="Prud Homme, Michel" sort="Prud Homme, Michel" uniqKey="Prud Homme M" first="Michel" last="Prud'Homme">Michel Prud'Homme</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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